Structure of HP1 Chromodomain Bound to a Lysine 9-Methylated Histone H3 Tail
By S. Jacobs, S. Khorasanizadeh. Science, 2002
860 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/0d7a53ea965fadc3ac607d30dddbd136b8c2be2f
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In Molecular Biology
- Yi Zhang
- S. Khorasanizadeh
- C. D. Allis
- Paul Tempst
- H. Erdjument‐Bromage
- W. Fischle
- Yanming Wang
- J. Min
Citations in the corpus
- Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. (2003, methodology): “The construct for the expression of the chromodomain of HP1 (residues 17–76) has been described previously (Jacobs and Khorasanizadeh 2002) ) were swapped using staggered PCR by incorporation of overlapping oligonucleotides .”
- Reading protein modifications with interaction domains (2006, background): “As with phosphorylation-dependent recognition, these interactions are rather simple, in the sense that a single chromodomain or bromodomain typically recognizes a suitably modified Lys residue in the context of a short peptide motif of defined sequenc”
- How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers (2007, background): “Molecular and mechanistic insights into chromodomain recognition of methyllysine marks has emerged from energetic, structural and mutagenic analyses of HP1 bound to H3K9me peptide”
- Interpreting thelanguage of histone and DNA modifications (2014, background): “For example, UHRF1 binding to H3K9me3-containing nucleosomes was enhanced by CpG methylation, consistent with the identified functions of its TTD-PHD histone binding module [104] and SRA domain [150–153].”
- SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. (2002, background): “The H3-K9 methylation (H3-MeK9) mark establishes a high-affinity binding site for the recruitment of the HP1 family of heterochromatin proteins through its chromodomain (Jacobs et al. 2001; Jacobs and Khorasanizadeh 2002).”