Worldwide emergence of resistance to antifungal drugs challenges human health and food security

By Matthew Fisher, N. Hawkins, D. Sanglard, Sarah J. Gurr. Science, 2018

1,294 citations recorded by the source corpus.

The recent rate of emergence of pathogenic fungi that are resistant to the limited number of commonly used antifungal agents is unprecedented. The azoles, for example, are used not only for human and animal health care and crop protection but also in antifouling coatings and timber preservation. The ubiquity and multiple uses of azoles have hastened the independent evolution of resistance in many environments. One consequence is an increasing risk in human health care from naturally occurring opportunistic fungal pathogens that have acquired resistance to this broad class of chemicals. To avoid a global collapse in our ability to control fungal infections and to avoid critical failures in medicine and food security, we must improve our stewardship of extant chemicals, promote new antifungal discovery, and leverage emerging technologies for alternative solutions.

Subfields: Cell Biology, Infectious Diseases, Insect Science

View Paper: https://www.semanticscholar.org/paper/0d44ed24c684f9a33c7220fec1df451f298d8520

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Citations in the corpus

• The Most Important Fungal Diseases of Cereals—Problems and Possible Solutions (2021, background): “However, it has been noted that individual species are developing resistance to the active substances contained in plant protection products [26].”