Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer.
By Y. Imamura, T. Mukohara, Y. Shimono, Y. Funakoshi, N. Chayahara, M. Toyoda, N. Kiyota, S. Takao, S. Kono, T. Nakatsura and 1 more. Oncology Report, 2015
767 citations recorded by the source corpus.
Subfields: Biomedical Engineering, Oncology
View Paper: https://www.semanticscholar.org/paper/0d41be7530c21a5cb5a52adeb114bdf06e727f0e
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biomedical Engineering
In Oncology
Citations in the corpus
- 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs (2018, background): “5% when in spheroids, suggesting that the spheroids had a greater G0‐dormant subpopulation that was responsible for its resistance to paclitaxel (Imamura et al., 2015).”
- Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning (2018, background): “Spheroids, but not 2D cultures, of patient-derived breast cancer cells simulated tumor characteristics in vivo such as hypoxia, dormancy, anti-apoptotic features and drug resistance (Imamura et al., 2015).”
- Is It Time to Start Transitioning From 2D to 3D Cell Culture? (2020, methodology): “The cells exhibited multidrug resistance, displayed stem-cell like traits, and cell motility was increased (Imamura et al., 2015).”
- Modeling Physiological Events in 2D vs. 3D Cell Culture. (2017, background): “A recent study has indicated that the formation of dense spheroids can prevent apoptosis in some breast cancer cell lines when exposed to cancer drugs such as paclitaxel (62).”