Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature

By B. Salehi, S. Upadhyay, İ. ERDOĞAN ORHAN, Sumali L.D. Jayaweera, Daniel A Dias, F. Sharopov, Yasaman Taheri, N. Martins, Navid Baghalpour, William C. Cho and 1 more. Biomolecules, 2019

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α- and β-pinene are well-known representatives of the monoterpenes group, and are found in many plants’ essential oils. A wide range of pharmacological activities have been reported, including antibiotic resistance modulation, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti-Leishmania, and analgesic effects. This article aims to summarize the most prominent effects of α- and β-pinene, namely their cytogenetic, gastroprotective, anxiolytic, cytoprotective, anticonvulsant, and neuroprotective effects, as well as their effects against H2O2-stimulated oxidative stress, pancreatitis, stress-stimulated hyperthermia, and pulpal pain. Finally, we will also discuss the bioavailability, administration, as well as their biological activity and clinical applications.

Subfields: Biochemistry, Cellular and Molecular Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/0d1c05c801d8aa6fa00110e5dfc792da7761086d