Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer.

By M. Snaebjornsson, Sudha Janaki-Raman, A. Schulze. Cell Metabolism, 2019

912 citations recorded by the source corpus.

Altered lipid metabolism is among the most prominent metabolic alterations in cancer. Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor formation. Lipids are a highly complex group of biomolecules that not only constitute the structural basis of biological membranes but also function as signaling molecules and an energy source. Here, we summarize recent evidence implicating altered lipid metabolism in different aspects of the cancer phenotype and discuss potential strategies by which targeting lipid metabolism could provide a therapeutic window for cancer treatment.

Subfields: Biochemistry, Cancer Research

View Paper: https://www.semanticscholar.org/paper/0cff91474d7376241d507bea4be2fa6a2d005145

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Citations in the corpus

• Targeting p53 pathways: mechanisms, structures and advances in therapy (2023, background): “Since tumor cells need to accumulate or synthesize lipids to promote growth and proliferation, 104 p53 promotes lipolysis leading to tumor suppression.”