Neuroplasticity — Exercise-Induced Response of Peripheral Brain-Derived Neurotrophic Factor

By K. Knaepen, Maaike Goekint, E. Heyman, Romain Meeusen. Sports Medicine, 2010

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The Effects of Acute Exercise on Mood, Cognition, Neurophysiology, and Neurochemical Pathways: A Review (2016, background): “In humans, acute exercise stimulates the peripheral increase of these three neurotrophins from sites including the liver, muscles, and blood cells [161, 162].”
A review of lifestyle factors that contribute to important pathways associated with major depression: diet, sleep and exercise. (2013, neutral): “synthesis, release, absorption and degradation) (Knaepen et al., 2010).”
The effects of acute exercise on cognitive performance: a meta-analysis. (2012, result): “As an example, studies testing the effects of acute exercise on circulating BDNF indicate that high intensity protocols result in larger increases than do low-intensity protocols (Knaepen et al., 2010).”
Exercise is the real polypill. (2013, background): “The antidepressive effect of the physical exercise correlates with increased levels of mature BDNF, and proBDNF proteolytic cleavage-related genes, p11 and tPA.”
Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults (2016, background): “S1) and found large fluctuations in both serumand plasmaBDNF (see also Knaepen et al., 2010 for discussion).”