Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells.

By Alex M. Chen, Dongguang Wei, D. Stueber, O. Taratula, T. Minko, Huixin He. Small, 2009

629 citations recorded by the source corpus.

Subfields: Biomaterials, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0cc3aedcf82588e76ba8082ce13d4e7d7455fec3

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In Biomaterials

1. A. Nel
2. Tian Xia
3. J. Zink
4. M. Liong
5. Liangfang Zhang

In Molecular Biology

1. Zongxi Li
2. Huan Meng
3. Tian Xia
4. Liangfang Zhang
5. A. Nel
6. C. J. Hu
7. M. Liong
8. J. Zink

Citations in the corpus

• Mesoporous silica nanoparticles in medicine--recent advances. (2013, background): “Recent work [71,72] exploits the possibilities of simultaneous co-delivery of chemotherapeutic drugs and siRNAs targeting cellular survival mechanisms.”
• Engineered Design of Mesoporous Silica Nanoparticles to Deliver Doxorubicin and Pgp siRNA to Overcome Drug Resistance in a Cancer Cell Line (2010, positive): “There are reports demonstrating that compared to the free drug, dual delivery with a nucleic acid is capable of enhancing the efficacy in a synergistic fashion.(16,17) Chen et al.”
• Nanoparticle-based combination therapy toward overcoming drug resistance in cancer. (2012, methodology): “Mesoporous silica nanoparticles, for instance, have been used to co-deliver MDR-targeted siRNA and DOX following surface coating with PEI [67] and with amine-terminated dendrimers [27].”
• Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies. (2016, methodology): “MSNPS have been used to load both iRNA and anticancer drugs simultaneously (Chen et al., 2009).”
• Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals (2019, background): “designed a co-deliv ry sys em for the simult neous administration of siRNA and DOX, consid rably modified the toxic effects of DOX (by ~132 times) [191].”
• Sol-gel based materials for biomedical applications (2016, methodology): “Gareth J. Owens a,1, Rajendra K. Singh b,c,1, Farzad Foroutan a, Mustafa Alqaysi a, Cheol-Min Han b,c, Chinmaya Mahapatra b,c, Hae-Won Kimb,c,d,⇑, Jonathan C. Knowles a,b,⇑ aDepartment of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, 256 Gray’s Inn Roa”