Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2 Is Required for Activation of NF-κB in Response to Diverse Cellular Stresses

By Hao Jiang, S. A. Wek, Barbara C. McGrath, D. Scheuner, R. Kaufman, D. Cavener, R. Wek. Molecular and Cellular Biology, 2003

389 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0c9deae5011efadd23c5c99addc223fe29308729

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. G. Hotamışlıgil
2. Sanjeev Gupta
3. A. Gorman
4. N. Donnelly
5. Afshin Samali

In Molecular Biology

1. G. Hotamışlıgil
2. Afshin Samali
3. A. Gorman
4. Sanjeev Gupta
5. R. Kaufman
6. N. Donnelly
7. H. Malhi
8. D. Ron

Citations in the corpus

• The eIF2α kinases: their structures and functions (2013, positive): “The eIF2α kinases play a key role in the activation of NF-κB in response to many stimuli, through eIF2α phosphorylation [42, 94], and as discussed above, in the case of PKR activation of NF-κB may even be direct [104].”
• The interaction of hepatic lipid and glucose metabolism in liver diseases. (2012, background): “NFjB regulates inflammatory signaling (IL-6, TNFa), and ATF4 regulates glucose metabolism [74,75].”
• Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease (2010, positive): “Recent studies have shown that NF-kB can be activated through this pathway via translational suppression of inhibitory kappa B (IkB), resulting in the regulation of mediators of inflammation (Deng et al., 2004; Jiang et al., 2003) such as IL-6 and TNF-a.”
• Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1α-Mediated NF-κB Activation and Down-Regulation of TRAF2 Expression (2006, background): “However, the mechanism of NF-B activation does not seem to involve IB degradation ( 19 ).”
• Endoplasmic Reticulum Stress in Liver Disease (2010, background): “Phosphorylation of eIF2α with subsequent translation attenuation reduces synthesis of IκB with consequent activation of the transcription factor NFκB as part of the response to stress [60, 147].”
• The role of the unfolded protein response in tumour development: friend or foe? (2004, neutral): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9451">PERK activatio”