Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates.

By F. Grün, Hajime Watanabe, Zaman Zamanian, Lauren Maeda, K. Arima, Ryan Cubacha, D. Gardiner, J. Kanno, T. Iguchi, B. Blumberg. Molecular Endocrinology, 2006

613 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Molecular Biology, Ocean Engineering

View Paper: https://www.semanticscholar.org/paper/0c983b9cafe351058ca2b163f52bd83f856dcc2f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Health, Toxicology and Mutagenesis

1. Cristina Casals-Casas
2. B. Desvergne
3. R. Cowie

In Molecular Biology

1. R. Cowie
2. K. Hayes
3. S. Thiengo
4. E. Strong

Citations in the corpus

• Insights from an Integrated View of the Biology of Apple Snails (Caenogastropoda: Ampullariidae) (2015, background): “…(TBT) induces lipid and fatty acid accumulation in female M. cornuarietis according to Janer et al. (2007), just as organotin compounds induce adipogenesis in vertebrates through interaction with retinoid X receptor (RXR) and peroxisome proliferator-activated γ receptor (Grün et al., 2006).”
• Metabolism Disrupting Chemicals and Metabolic Disorders (2016, neutral): “Consistent with animal studies [491], a number of human studies —including studies among children and numerous studies in adults— suggest that DEHP is more strongly associated than are other phthalates with diabetes and other markers of impaired glucose metabolism [365, 492-495], perhaps because of ”
• EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. (2015, background): “TBT acts as an agonist of PPAR and retinoid X receptor (RXR) at nanomolar levels and promotes adipogenesis in the preadipocyte cell line 3T3-L1 (184, 207).”
• Endocrine-disrupting chemicals: an Endocrine Society scientific statement. (2009, background): “have been reviewed recently (435, 436, 444) and represent”
• Endocrine disruptors: from endocrine to metabolic disruption. (2011, background): “The fat mass—but not the total body weight—of in utero TBT-treated mice significantly increases in adulthood, supporting the conclusion that embryonic and chronic lifetime organotin exposure may contribute to the incidence of obesity through disruption of the PPARγ:RXR pathway (28).”