Network abnormalities and interneuron dysfunction in Alzheimer disease

By J. Palop, L. Mucke. Nature Reviews Neuroscience, 2016

918 citations recorded by the source corpus.

The function of neural circuits and networks can be controlled, in part, by modulating the synchrony of their components' activities. Network hypersynchrony and altered oscillatory rhythmic activity may contribute to cognitive abnormalities in Alzheimer disease (AD). In this condition, network activities that support cognition are altered decades before clinical disease onset, and these alterations predict future pathology and brain atrophy. Although the precise causes and pathophysiological consequences of these network alterations remain to be defined, interneuron dysfunction and network abnormalities have emerged as potential mechanisms of cognitive dysfunction in AD and related disorders. Here, we explore the concept that modulating these mechanisms may help to improve brain function in these conditions.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/0c8e75e4658820f542985ef1ce1aff0968824128

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Citations in the corpus

• APP mouse models for Alzheimer's disease preclinical studies (2017, neutral): “Box 1 summarizes the mutant APP or APP/PS-overexpressing mouse models, including prospective ideas that may be experimentally validated to better consoli-date the APP overexpression paradigm with human AD clinical pathogenesis (Huang & Mucke, 2012; Saito et al , 2014; Palop & Mucke, 2016).”
• Neural Mechanisms Underlying Brain Gamma Entrainment after Periodic Auditory Stimulation at Gamma Frequency (2024, background): “The disrupted network also affects cross-frequency coupling functions like theta-gamma couplings, which are important for memory and cognitive performance [4, 6, 12–14].”