Cu-free click cycloaddition reactions in chemical biology

By John C Jewett, Carolyn R. Bertozzi. Chemical Society Reviews, 2010

1,436 citations recorded by the source corpus.

Bioorthogonal chemical reactions are paving the way for new innovations in biology. These reactions possess extreme selectivity and biocompatibility, such that their participating reagents can form covalent bonds within richly functionalized biological systems—in some cases, living organisms. This tutorial review will summarize the history of this emerging field, as well as recent progress in the development and application of bioorthogonal copper-free click cycloaddition reactions.

Subfields: Molecular Biology, Organic Chemistry, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/0c88ccb67376b516ada1ee776d7daca3116392d5

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In Molecular Biology

1. M. Finn
2. Craig S Mckay

In Organic Chemistry

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In Radiology, Nuclear Medicine and Imaging

1. M. Finn
2. Craig S Mckay

Citations in the corpus

• Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation (2014, background): “…reactions have emerged as highly specific tools that can be used for investigating the dynamics and function of biomolecules in living systems (Jewett and Bertozzi, 2010; Lang and Chin, 2014; Lim and Lin, 2010b; Patterson et al., 2014; Prescher and Bertozzi, 2005; Sletten and Bertozzi, 2009).”