A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior

By M. Carlén, K. Meletis, Joshua H. Siegle, Jessica A. Cardin, K. Futai, D. Vierling-Claassen, C. Rühlmann, S. R. Jones, Karl Deisseroth, M. Sheng and 2 more. Molecular Psychiatry, 2011

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Synchronous recruitment of fast-spiking (FS) parvalbumin (PV) interneurons generates gamma oscillations, rhythms that emerge during performance of cognitive tasks. Administration of N-methyl-D-aspartate (NMDA) receptor antagonists alters gamma rhythms, and can induce cognitive as well as psychosis-like symptoms in humans. The disruption of NMDA receptor (NMDAR) signaling specifically in FS PV interneurons is therefore hypothesized to give rise to neural network dysfunction that could underlie these symptoms. To address the connection between NMDAR activity, FS PV interneurons, gamma oscillations and behavior, we generated mice lacking NMDAR neurotransmission only in PV cells (PV-Cre/NR1f/f mice). Here, we show that mutant mice exhibit enhanced baseline cortical gamma rhythms, impaired gamma rhythm induction after optogenetic drive of PV interneurons and reduced sensitivity to the effects of NMDAR antagonists on gamma oscillations and stereotypies. Mutant mice show largely normal behaviors except for selective cognitive impairments, including deficits in habituation, working memory and associative learning. Our results provide evidence for the critical role of NMDAR in PV interneurons for expression of normal gamma rhythms and specific cognitive behaviors.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/0c2b909388814687d286ccb7695c40307c358b3a

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Biological Psychology : Stress (2016, positive): “…2008), but recent evidence emphasises interactions between interneurons and pyramidal cells and the centrality of the role of the NMDA receptor in production of cortical oscillations (Cardin et al., 2009; Carlen et al., 2012; Carracedo et al., 2013; Kirli, Ermentrout, & Cho, 2014; Sivarao, 2015).”