Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression
By Anthony A. Grace. Nature Reviews Neuroscience, 2016
1,048 citations recorded by the source corpus.
The dopamine system is unique among the brain's modulatory systems in that it has discrete projections to specific brain regions involved in motor behaviour, cognition and emotion. Dopamine neurons exhibit several activity patterns — including tonic and phasic firing — that are determined by a combination of endogenous pacemaker conductances and regulation by multiple afferent systems. Emerging evidence suggests that disruptions in these regulatory systems may underlie the pathophysiology of several psychiatric disorders, including schizophrenia and depression.
Subfields: Cellular and Molecular Neuroscience, Pharmacology
View Paper: https://www.semanticscholar.org/paper/0c2b80e19e873a3f49bf32c8b3cdec12dad16253
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In Cellular and Molecular Neuroscience
In Pharmacology
Citations in the corpus
- Dopamine System Dysregulation in Major Depressive Disorders (2017, background): “The mPFC does not project directly to the vSub (Vertes et al., 2006), and we have shown that this effect was mediated by, at least in part, the nucleus reuniens of the thalamus (Zimmerman and Grace, 2016).”