Multimarker Approach to Risk Stratification in Non-ST Elevation Acute Coronary Syndromes: Simultaneous Assessment of Troponin I, C-Reactive Protein, and B-Type Natriuretic Peptide

By M. Sabatine, D. A. Morrow, J. D. de Lemos, C. Gibson, S. Murphy, N. Rifai, C. Mccabe, E. Antman, C. Cannon, E. Braunwald. Circulation, 2002

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N‐Terminal Pro‐Brain Natriuretic Peptide and Other Risk Markers for the Separate Prediction of Mortality and Subsequent Myocardial Infarction in Patients With Unstable Coronary Artery Disease: A Global Utilization of Strategies To Open occluded arteries (GUSTO)‐IV Substudy (2003, background): “Mortality There was increased mortality among patients with increasing quartiles of NT-proBNP (Figure 1). The Kaplan-Meier survival curves for the quartiles separated early, and already at 48 hours after randomization, the difference in mortality between the quartiles was statistically significant (”
Protein biomarker discovery and validation: the long and uncertain path to clinical utility (2006, background): “, three to five) markers used either individually or as part of integrated panels will be required for most applications, and the performance advantages of panels have been confirmed in several recent publication”
2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. (2014, methodology): “11956114(61) Use of multiple biomarkers to predict MACE in NSTE-ACS Multi-institution prospective 450 (OPUS-TIMI 16) 1,635 (TACTICS-18) TnI, CRP, BNP in combination vs.”