The syntenic relationship of the zebrafish and human genomes.

By W. B. Barbazuk, Ian Korf, Candy Kadavi, J. Heyen, Stephanie Tate, E. Wun, J. Bedell, J. McPherson, S. Johnson. Genome Research, 2000

648 citations recorded by the source corpus.

The zebrafish is an important vertebrate model for the mutational analysis of genes effecting developmental processes. Understanding the relationship between zebrafish genes and mutations with those of humans will require understanding the syntenic correspondence between the zebrafish and human genomes. High throughput gene and EST mapping projects in zebrafish are now facilitating this goal. Map positions for 523 zebrafish genes and ESTs with predicted human orthologs reveal extensive contiguous blocks of synteny between the zebrafish and human genomes. Eighty percent of genes and ESTs analyzed belong to conserved synteny groups (two or more genes linked in both zebrafish and human) and 56% of all genes analyzed fall in 118 homology segments (uninterrupted segments containing two or more contiguous genes or ESTs with conserved map order between the zebrafish and human genomes). This work now provides a syntenic relationship to the human genome for the majority of the zebrafish genome.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0bfb966fc415481e353c78ededf3984b32b4043c

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In Genetics

1. Y. Van de Peer
2. R. Neira
3. Axel Meyer
4. Patricia Iturra
5. J. Taylor
6. I. Braasch
7. C. Araneda
8. P. Ulloa

In Molecular Biology

1. Y. Van de Peer
2. R. Neira
3. Axel Meyer
4. Patricia Iturra
5. Carl Smith
6. J. Taylor
7. C. Lawrence
8. R. Spence

Citations in the corpus

• The behaviour and ecology of the zebrafish, Danio rerio (2007, background): “…is that as a vertebrate it is more comparable to humans than invertebrate model species such as Drosophila melanogaster (Postlethwait et al., 1998; Barbazuk et al., 2000), while being more tractable to genetic and embryological manipulation than mammalian model species such as mice, in which such…”
• Guidelines on nicotine dose selection for in vivo research (2007, background): “Large syntenic regions between human and zebrafish genomes (Barbazuk et al. 2000) will aid in the identification of additional zebrafish nAChRs as well as validate the zebrafish as a model system to explore the effects of nicotine relevant to human nAChRs.”
• Zebrafish as a model organism for nutrition and growth: towards comparative studies of nutritional genomics applied to aquacultured fishes (2011, background): “The existence of shared synteny between human and zebrafish genomes has been demonstrated (Barbazuk et al. 2000), as well as between zebrafish and green spotted pufferfish (Tetraodon nigriviridis) (Woods et al. 2005).”
• Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish (2009, background): “In addition to larvae studies, behavioral phenotyping of adult zebrafish also represents an important direction of research [14] [15] [16] [17].”
• Genome duplication, a trait shared by 22000 species of ray-finned fish. (2003, background): “…new, potentially adaptive functions in duplicated genes is growing but still quite small, e.g., antifreeze proteins in Antarctic fishes (Cheng and Chen 1999), color vision in new-world monkeys (Dulai et al. 1999), thermal adaptation in Escherichia coli (Riehle et al. 2001) and RNA digestion in…”