Respiratory epithelial cells orchestrate pulmonary innate immunity
By Jeffrey A. Whitsett, T. Alenghat. Nature Immunology, 2014
727 citations recorded by the source corpus.
The epithelial surfaces of the lungs are in direct contact with the environment and are subjected to dynamic physical forces as airway tubes and alveoli are stretched and compressed during ventilation. Mucociliary clearance in conducting airways, reduction of surface tension in the alveoli, and maintenance of near sterility have been accommodated by the evolution of a multi-tiered innate host-defense system. The biophysical nature of pulmonary host defenses are integrated with the ability of respiratory epithelial cells to respond to and 'instruct' the professional immune system to protect the lungs from infection and injury.
Subfields: Immunology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/0bbb6161fcda935a3a26dea80df5d713362d9016
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Citations in the corpus
- New developments in goblet cell mucus secretion and function (2015, unknown): “Interestingly, recent observations suggest that the SPDEF transcription factor is required for the normal pulmonary Th2 inflammatory response and goblet cell hyperplasia.(58) SPDEF regulates goblet cell maturation and differentiation in both the lung and intestine,(25,58,59) further suggesting that ”
- Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma (2020, background): “The pulmonary epithelium is a physical barrier that produces antimicrobial mucus and surfactant proteins, facilitates host-microbiota interactions to control mucosal immunity, and is critical for tumor development (Whitsett and Alenghat, 2015).”