Foundations for engineering biology

By Drew Endy. Nature, 2005

1,546 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0ba753d06a5c04036dca803073a925217f3d5384

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In Biomedical Engineering

In Molecular Biology

Citations in the corpus

Engineering BioBrick vectors from BioBrick parts (2008, background): “Very little work has been done to standardize the components or processes underlying genetic engineering [6].”
Precise and reliable gene expression via standard transcription and translation initiation elements (2013, background): “(P:U)ij represents the effect of any interaction between the ith transcriptional element and jth translational element; (P:GOI)ik represents the effect of interaction between the ith transcriptional element and kth (1)”
Systems medicine: the future of medical genomics and healthcare (2009, neutral): “properties from modular components [18-21].”
A Synthetic Genetic Edge Detection Program (2009, background): “Living cells can be programmed with genetic parts, such as promoters, transcription factors and metabolic genes (Andrianantoandro et al., 2006; Benner and Sismour, 2005; Canton et al., 2008; Endy, 2005; Haseltine and Arnold, 2007).”
PromoterPredict: sequence-based modelling of Escherichia coli σ70 promoter strength yields logarithmic dependence between promoter strength and sequence (2018, background): “Such an understanding could be vital in the prediction of promoter strengths in different contexts, as well as the forward design of promoters in ﬁ nely-tuned genetic circuits (see Endy, 2005 ; De Mey et al., 2007 ; Salis, Mirsky & Voigt, 2009 ; Li & Zhang, 2014 ).”
The Commodification of Emergence: Systems Biology, Synthetic Biology and Intellectual Property (2008, background): “Others see synthetic biology as a distinct field with autonomous aims (Endy, 2005).”
The Standard European Vector Architecture (SEVA): a coherent platform for the analysis and deployment of complex prokaryotic phenotypes (2012, background): “While these circum-stances have not limited laboratory studies, the necessity of ﬁxed formats for vector organization and designation has become increasingly apparent as we enter the era of Systems and Synthetic Biology (2,3).”
Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, neutral): “The bottom-up approach is also likely to enrich synthetic biology [2046, 2047, 2048, 2049, 2050, 2051, 2052, 2053].”
A synchronized quorum of genetic clocks (2010, positive): “The genetic circuits approach to synthetic biology involves the forward engineering of relatively small gene networks using computational modelling 20,21 .”
The Human Sciences in a Biological Age (2013, background): “…processes can be construed as assemblies of parts specified by their gene sequences, and these parts can be fabricated and connected together to make something completely new . . . to create the organisms that evolution forgot (Baker et al., 2006; Endy, 2005; Royal Academy of Engineering, 2009).”
RNA synthetic biology (2006, background): “An immediate challenge for the field is the creation of an infrastructure, comprising modular and scalable functional component”
BglBricks: A flexible standard for biological part assembly (2010, background): “required to iteratively combine any two parts, we can assemble multi-part devices and characterize the rules of functional composition for each part in the context of other parts [3,4].”
Measuring the activity of BioBrick promoters using an in vivo reference standard (2009, background): “Background The engineering of many-component, synthetic biological systems is being made easier by the development of collections of reusable, standard biological parts [1-6].”
Synthetic Biology: Social and Ethical Challenges (2008, background): “To achieve this engineering abstraction research is intensively focused both on the standardization of these interchangeable parts and the decoupling of complex systems into more manageable components [Endy 2005].”