Antibacterial activity of plant extracts and phytochemicals on antibiotic-resistant bacteria

By G. G. Nascimento, J. Locatelli, Paulo C.D. Freitas, G. L. Silva. 2000

1,963 citations recorded by the source corpus.

The antimicrobial activity of plant extracts and phytochemicals was evaluated with antibiotic susceptible and resistant microorganisms. In addition, the possible synergistic effects when associated with antibiotics were studied. Extracts from the following plants were utilized: Achillea millifolium (yarrow), Caryophyllus aromaticus (clove), Melissa offficinalis (lemon-balm), Ocimun basilucum (basil), Psidium guajava (guava), Punica granatum (pomegranate), Rosmarinus officinalis (rosemary), Salvia officinalis (sage), Syzygyum joabolanum (jambolan) and Thymus vulgaris (thyme). The phytochemicals benzoic acid, cinnamic acid, eugenol and farnesol were also utilized. The highest antimicrobial potentials were observed for the extracts of Caryophyllus aromaticus and Syzygyum joabolanum, which inhibited 64.2 and 57.1% of the tested microorganisms, respectively, with higher activity against antibiotic-resistant bacteria (83.3%). Sage and yarrow extracts did not present any antimicrobial activity. Association of antibiotics and plant extracts showed synergistic antibacterial activity against antibiotic-resistant bacteria. The results obtained with Pseudomonas aeruginosa was particularly interesting, since it was inhibited by clove, jambolan, pomegranate and thyme extracts. This inhibition was observed with the individual extracts and when they were used in lower concentrations with ineffective antibiotics.

Subfields: Food Science, Plant Science

View Paper: https://www.semanticscholar.org/paper/0ba3efbcb8ae3d984ef80a42fccec45f3ca7b849

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Citations in the corpus

• Performance, immunity, serum biochemical and hematological parameters in broiler chicks fed dietary thyme as alternative for an antibiotic growth promoter (2010, positive): “the growth performance of birds are their probable antioxidant and antibacterial effects in the intestine (Nascimento et al., 2000).”
• Inhibitory action of some essential oils and phytochemicals on the growth of various moulds isolated from foods (2005, background): “…flavones are some phytochemicals that have been studied regarding their antimicrobial spectrum on some bacterial and fungi species (Megalla et al., 1980; Gnamanickman and Mansfield, 1981; Odebyi et al., 1984; Karapnan, 1990; Delaquis and Mazza, 1995; Helander et al., 1998; Nascimento et al., 2000).”