Bayesian classification for the selection of in vitro human embryos using morphological and clinical data
By Dinora Araceli Morales, Endika Bengoetxea, Pedro Larrañaga, Miguel García, Yosu Franco, Mónica Fresnada, Marisa Merino. 2008
75 citations recorded by the source corpus.
In vitro fertilization (IVF) is a medically assisted reproduction technique that enables infertile couples to achieve successful pregnancy. Given the uncertainty of the treatment, we propose an intelligent decision support system based on supervised classification by Bayesian classifiers to aid to the selection of the most promising embryos that will form the batch to be transferred to the woman's uterus. The aim of the supervised classification system is to improve overall success rate of each IVF treatment in which a batch of embryos is transferred each time, where the success is achieved when implantation (i.e. pregnancy) is obtained. Due to ethical reasons, different legislative restrictions apply in every country on this technique. In Spain, legislation allows a maximum of three embryos to form each transfer batch. As a result, clinicians prefer to select the embryos by non-invasive embryo examination based on simple methods and observation focused on morphology and dynamics of embryo development after fertilization. This paper proposes the application of Bayesian classifiers to this embryo selection problem in order to provide a decision support system that allows a more accurate selection than with the actual procedures which fully rely on the expertise and experience of embryologists. For this, we propose to take into consideration a reduced subset of feature variables related to embryo morphology and clinical data of patients, and from this data to induce Bayesian classification models. Results obtained applying a filter technique to choose the subset of variables, and the performance of Bayesian classifiers using them, are presented.
Subfields: Artificial Intelligence, Genetics, Statistics and Probability
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In Artificial Intelligence
Citations in the corpus
- Ethical Implementation of Artificial Intelligence to Select Embryos in In Vitro Fertilization (2021, background): “[32], who created interpretable hand-calculated features and applied a variety of classical machine learning algorithms to them.”