Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion

By Caroline Mauvezin, T. P. Neufeld. Autophagy, 2015

697 citations recorded by the source corpus.

Subfields: Epidemiology, Parasitology, Physiology

View Paper: https://www.semanticscholar.org/paper/0b1779f2b7a4efc93f2417f59c264cd69ee34410

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In Epidemiology

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Citations in the corpus

• Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory (2019, background): “The small molecule Bafilomycin A1 (BafA1) inhibits lysosomal activity by blocking the V-ATPase hydrogen pump and thus acidification of the lysosome (Mauvezin and Neufeld, 2015).”
• Autophagy pathway: Cellular and molecular mechanisms (2018, background): “BafA1 targets the vacuolar-type H-translocating ATPase on the lysosome to prevent lumenal acidification, and independently inhibits Ca-P60A/SERCA to disrupt autophagosome-lysosome fusion.(70)”