Renal function, neurohormonal activation, and survival in patients with chronic heart failure.

By Hans L. Hillege, A. Girbes, P. J. Kam, F. Boomsma, D. Zeeuw, A. Charlesworth, J. Hampton, D. V. Veldhuisen. Circulation, 2000

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Gut microbiota dysbiosis contributes to the development of hypertension (2017, background): “concern and a major risk factor for cardiovascular, cerebrovascular, and kidney diseases [14, 15].”
Chronic kidney disease and mortality risk: a systematic review. (2006, background): “PRIME II 2000 (13) RCT; PRIME II; The Netherlands Age 18 to 80 yr, CHF 1906 0.”
[Executive summary of the guidelines on the diagnosis and treatment of acute heart failure]. (2005, background): “However, even a mild-to-moderate increase in serum creatinine and/or decrease in glomerular filtration rate (GFR) are independently associated with a worse prognosis.(177,178) Concomitant acute renal failure requires the recognition and treatment of its associated disorders: anaemia, electrolyte abn”
Renal Insufficiency and Heart Failure: Prognostic and Therapeutic Implications From a Prospective Cohort Study (2004, neutral): “Heart rate, bpm 80 (17) 79 (15) 79 (15) 79 (16) 77 (14) 0.”
Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. (2001, background): “Although prior studies have suggested that reduced kidney function may be a risk factor for all-cause mortality (4,5), these studies did not provide a quantitative estimate of the relationship between the level of kidney function to mortality.”