High-speed optical frequency-domain imaging.

By S. Yun, G. Tearney, De Boer, N. Iftimia, B. Bouma. Optics Express, 2003

930 citations recorded by the source corpus.

We demonstrate high-speed, high-sensitivity, high-resolution optical imaging based on optical frequency-domain interferometry using a rapidly-tuned wavelength-swept laser. We derive and show experimentally that frequency-domain ranging provides a superior signal-to-noise ratio compared with conventional time-domain ranging as used in optical coherence tomography. A high sensitivity of -110 dB was obtained with a 6 mW source at an axial resolution of 13.5 microm and an A-line rate of 15.7 kHz, representing more than an order-of-magnitude improvement compared with previous OCT and interferometric imaging methods.

Subfields: Biomedical Engineering, Biophysics

View Paper: https://www.semanticscholar.org/paper/0ad92a69126dc99197a003f04aa0c3b60a9a2e81

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Citations in the corpus

An insight into optical metrology in manufacturing (2020, neutral): “Swept-source OCT (SS-OCT) is another kind of frequencydomain OCT with a frequency-tunable light source [305].”
In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography (2005, neutral): “Diabetes mellitus 5 (25) 3 (15) 5 (29) 0.”
Optical Coherence Tomography Angiography (2016, background): “Due to the slow speed of time-domain systems and the challenge posed by eye motion, volumetric angiography was not feasible until development of the two Fourier-domain OCT implementations: spectral-domain (SD-OCT)(14,15) and swept-source.(16,17) When first introduced, Fourier-domain OCT already had ”
Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging (2009, methodology): “Here we overcome these limitations by developing new methods and instrumentation for a second-generation OCT technology termed OFD”
High-speed optical coherence tomography: basics and applications. (2010, background): “[[28] initially, enabled for OCT imaging with 15kHz sweep rate and developing up to 115kHz [72,73]] and at present available commercially (Santec) at 50kHz scanning rate with almost 100% duty cycle.”
Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography. (2006, background): “In biomedical imaging with optical coherence tomography (OCT), [1] frequency-swept lasers have recently enabled imaging speeds of up to several ten thousand axial scans per second, which is 10 to 50 times faster than standard OCT detection techniques.[2-12] A further increase in the sweep rate is de”