Matrix metalloproteinases and their multiple roles in neurodegenerative diseases.

By Gary A. Rosenberg. Lancet Neurology, 2009

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The yak genome and adaptation to life at high altitude (2012, background): “As a master regulator of the cellular response to hypoxia, Hif-1 α triggers wide transcription of genes involved in angiogenesis, vasodilatation and energy metabolism 30–35 .”
The Role of Macrophage Phenotype in Vascularization of Tissue Engineering Scaffolds (2014, unknown): “M1secreted factors TNF-alpha, IL1-beta, and VEGF have each been shown to promote blood vessel sprouting by inducing an endothelial tip cell phenotype [43,55], while signaling from M2a macrophages promoted anastomosis (Fig.”
Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease (2009, background): “Activated MMP9 can degrade basement membranes, extracellular matrix proteins and tight junction proteins subsequently damaging the integrity of the BBB [31, 71, 100] and potentially leading to spontaneous cerebral hemorrhages.”
Tissue-Specific Functional Networks for Prioritizing Phenotype and Disease Genes (2012, background): “For example, Timp2 , which we have previously identified to be related to BMD [11], is also involved in the control and/or development of neurodegenerative disease [12].”