Tissue Doppler Echocardiographic Evidence of Reverse Remodeling and Improved Synchronicity by Simultaneously Delaying Regional Contraction After Biventricular Pacing Therapy in Heart Failure

By Cheuk-Man Yu, E. Chau, J. Sanderson, K. Fan, Man‐Oi Tang, W. Fung, Hong Lin, Shun-ling Kong, Y. Lam, M. Hill and 1 more. Circulation, 2002

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Long-term clinical effect of hemodynamically optimized cardiac resynchronization therapy in patients with heart failure and ventricular conduction delay. (2002, background): “This biventricular or LV pre-excitation apparently resynchronizes RV and LV contractions (11), as well as LV septal and lateral wall contractions (12,13).”
Cardiac resynchronization and death from progressive heart failure: a meta-analysis of randomized controlled trials. (2003, background): “Second, a reduction in progressive heart failure mortality is concordant with other known benefits of cardiac resynchronization such as improved exercise capacity, functional class, and quality of life.(17,21,23,27,29-35) Third, the favorable effect of cardiac resynchronization on progressive heart ”
Diabetic cardiomyopathy, causes and effects (2010, methodology): “How- ever, using tissueDoppler strain analysis andmeasurements of peak systolic velocity, subtle abnormalities in systolic function have been described in up to 24% of randomly selected patients with diabetes mellitus after excluding subjects with CAD or LVH [65, 66].”