Identification of selective norbornane-type aspartate analogue inhibitors of the glutamate transporter 1 (GLT-1) from the chemical universe generated database (GDB).

By E. Luethi, Kong T. Nguyen, Marc Bürzle, Lorenz C. Blum, Yoshiro Suzuki, M. Hediger, Jean-Louis Reymond. 2010

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SLC Transporters as Therapeutic Targets: Emerging Opportunities (2015, unknown): “Second, an astrocyte-based enzyme-linked immunosorbent assay has been developed to screen large compound libraries for molecules that can induce translation of silenced SLC1A2 transcripts, as the expression of EAAT2 protein is highly regulated at the translational level by extracellular factors 81 .”
The enumeration of chemical space (2012, methodology): “142 In each of these three cases, ligands were selected from GDB on the basis of pharmacophoric similarity to a reference ligand and prioritized for synthesis on the basis of docking scores to the corresponding target combined with retrosynthetic analysis.”