Long Noncoding RNAs in Cancer Pathways

By A. Schmitt, Howard Y. Chang. Cancer Cell, 2016

2,853 citations recorded by the source corpus.

Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular mechanisms are now providing the tools to functionally annotate these cancer associated transcripts, making these molecules attractive targets for therapeutic intervention in the fight against cancer.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/09e6701b119fcb6264cca9ac63e6bd1aa9fbcb2b

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In Cancer Research

1. David A. Baker
2. Y. Hao
3. P. ten Dijke

In Molecular Biology

1. David A. Baker
2. Y. Hao
3. P. ten Dijke

Citations in the corpus

• TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis (2019, background): “Aberrant expression and mutations in lncRNAs have been linked to tumorigenesis, metastasis, and tumor stage [125].”