The Catharanthus alkaloids: pharmacognosy and biotechnology.

By R. van der Heijden, D. I. Jacobs, W. Snoeijer, D. Hallard, R. Verpoorte. Current Medicinal Chemistry, 2004

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Drug discovery from medicinal plants. (2005, methodology): “Vinblastine and vincristine were isolated from Catharanthus roseus (L.) G. Don (Apocynaceae) (formerly Vinca rosea L.) and have been used clinically for over 40 years (van Der Heijden et al., 2004).”
Cellular and sub-cellular organisation of the monoterpenoid indole alkaloid pathway in Catharanthus roseus (2007, background): “Beside these three drugs, more than 130 other MIAs have been identified in this plant (van der Heijden et al. 2004).”
Manipulating indole alkaloid production by Catharanthus roseus cell cultures in bioreactors: from biochemical processing to metabolic engineering (2007, background): “The biosynthesis of indole alkaloids has been extensively studied and many details about enzymes and genes involved have been reported, yet many genes involved in the secologanin and catharanthine biosynthesis remain unknown (Verpporte et al. 1997; van der Heijden et al. 2004 ).”