Intrauterine infection and preterm delivery.

By Robert L. Goldenberg, J. Hauth, W. Andrews. New England Journal of Medicine, 2000

2,479 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Epidemiology, Microbiology

View Paper: https://www.semanticscholar.org/paper/09daa85b61eb27c373302395d57f34ecc1b9257e

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In Epidemiology

1. Roberto Romero
2. David A. Relman

Citations in the corpus

• The Role of Inflammation and Infection in Preterm Birth (2007, background): “Similarly, the evidence supporting the role of TNF-α in the mechanisms of preterm parturition includes: (1) TNF-α stimulates prostaglandin production by amnion, decidua, and myometrium;8 (2) human decidua can produce TNF-α in response to bacterial products; 166,167 (3) amniotic fluid TNF-α bioactivi”
• The infant microbiome development: mom matters (2014, neutral): “In the vagina, the increasing presence of lactobacilli through the course of gestation helps maintain a low pH, thereby limiting bacterial diversity and preventing bacteria from ascending to the uterus, where they can infect the amniotic fluid, placenta, and fetus [28,29].”
• Prolonged Initial Empirical Antibiotic Treatment is Associated with Adverse Outcomes in Premature Infants (2011, background): “premature labor, premature rupture of membranes, and chorioamnionitis often prompt initiation of empirical antibiotic treatment(4).”
• Microbial Prevalence, Diversity and Abundance in Amniotic Fluid During Preterm Labor: A Molecular and Culture-Based Investigation (2008, background): “A strong body of evidence suggests that occult intra-uterine infection plays a major role in preterm labor and delivery [7].”
• Bronchopulmonary dysplasia. (2001, background): “Preterm births continue to be the major challenge in obstetrics and neonatology, accounting for most of the perinatal mortality and long-term neurologic morbidity among newborns (58).”
• Amniotic Infection Syndrome: Nosology and Reproducibility of Placental Reaction Patterns (2003, background): “Premature delivery is the major cause of perinatal morbidity and mortality in the United States accounting for 70% of deaths, nearly half of cerebral palsy, and a substantial proportion of other disorders including chronic lung disease, mental retardation, and sensorineural impairment [ 20 ].”
• Epidemiology and causes of preterm birth (2008, background): “66, 67 The mechanisms by which intrauterine infections lead to preterm labour are related to activation of the innate immune system.”
• Inflammation and Pregnancy (2006, background): “Among all causes of preterm labor and delivery, intrauterine infection is one of the most frequent conditions leading to preterm labor and the pathogenic mechanisms are related to activation of the innate immune system.(50) Microorganisms are recognized by pattern-recognition receptors, like TLRs, t”