Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

By Y. Simoni, Etienne Becht, M. Fehlings, C. Loh, S. Koo, K. Teng, J. Yeong, R. Nahar, Tong Zhang, H. Kared and 22 more. Nature, 2018

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Tumor-infiltrating lymphocytes in the immunotherapy era (2020, background): “These cells have diverse phenotypes but lack CD39 expression, which distinguishes them from the tumor-specific TRM cell population.(29) Interestingly, it has been demonstrated that although unspecific for tumor antigens, these bystander cells are capable of contributing to the antitumor response.”
Dysfunctional CD8+ T cells form a proliferative, dynamically regulated compartment within human melanoma (2018, background): “1 SCARNA17 TMBIM1 GPR183 KLF3 CD48 NSG1 TPT1 ST6GAL1 SATB1 XBP1 PABPC1 KLF13 PRKCB MYBL1 MIR3654 CALCOCO2 TMEM123 CDKN2D CALM1 FOSB S1PR1 DYRK2 TSC22D3 C1orf162 PRPF38B EEF2 SNORD100 S100A10 STAT4 SNORA52 BTG1 EEF1A1P5 SAMD3 RORA TRGC1 PLAC8 LYAR KLRG1 ANXA1 SELL C1orf21 KLRB1 TCF7 CX3CR1 CXCR4 FGFB”
CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. (2019, background): “In addition, blockade of the PD-1 pathway results in an increase in glucose in the tumor microenvironment that also likely contributes to improved TIL function and tumor regression (116).”