Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

By B. Cravatt, K. Demarest, M. Patricelli, M. Bracey, Dan K. Giang, B. Martin, A. Lichtman. Proceedings of the National Academy of Sciences of the United States of America, 2001

1,305 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/0989df1439c9c2a6766aa679c76ae65d5712e775

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Citations in the corpus

The Endocannabinoid System as an Emerging Target of Pharmacotherapy (2006, background): “…the actions of exogenous anandamide, and the appearance of tonic signaling by endogenous anandamide, resulting in CB1 receptor-mediated hypoalgesia (Cravatt et al., 2001; Lichtman et al., 2004b), reduced anxiety (Kathuria et al., 2003), antidepressant activity (Gobbi et al., 2006), and lowering of…”
The molecular logic of endocannabinoid signalling (2003, background): “FAAH tightly controls brain concentrations of these compound”
Cannabinoid receptors and their ligands. (2002, neutral): “185, 186 When anandamide is not protected from hydrolysis by FAAH, it can still produce hypokinesia, catalepsy, hypothermia and antinociception in mice, albeit with reduced potency.”
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. (2005, background): “To test the role of altered synthesis versus degradation in the elevation of hepatic anandamide levels, we measured the activities of N-acyltransferase (NAT), the rate-limiting step in anandamide synthesis (23), and of fatty acid amidohydrolase (FAAH), the enzyme responsible for the metabolism of an”
The endocannabinoid system and its therapeutic exploitation (2004, neutral): “Genetically engineered mice lacking this enzyme have also been develope”
The pharmacological landscape and therapeutic potential of serine hydrolases (2012, background): “Genetic deletion or chemical inactivation of FAAH in rodents increases the levels of anandamide and related fatty acid amides, resulting in analgesia, anti-inflammatory effects, anxiolysis and antidepressant effects without causing the psychotropic side effects typically observed with direct cannabi”
The endocannabinoid system drives neural progenitor proliferation (2005, positive): “The functional relevance of the eCB system in vivo was determined using FAAH knockout mice that posses increased brain levels of eCBs (6).”
Pharmacokinetics and Pharmacodynamics of Cannabinoids (2003, background): “resulted in supersensitivity to anandamide and enhanced endogenous cannabinoid signalling.[159] 4.”
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects (2008, background): “Other MAGs, such as monopalmitoylglycerol (14, PG) and mono-oleoylglycerol (15, OG), and their corresponding free fatty acids palmitic acid (16) and oleic acid (17), respectively, were not significantly (P4 0.”
Neurobiological Interactions Between Stress and the Endocannabinoid System (2016, background): “However, to date, studies have clearly identified the physiological significance of FAAH and MAGL as regulators of eCB levels as pharmacological or genetic inactivation of these two enzymes results in profound accumulation of AEA and 2-AG, respectively (Cravatt et al, 2001; Long et al, 2009).”