Magnetic Nanomaterials for Hyperthermia-based Therapy and Controlled Drug Delivery

By Challa S. S. R. Kumar, Faruq Mohammad. Advanced Drug Delivery Reviews, 2011

1,556 citations recorded by the source corpus.

Previous attempts to review the literature on magnetic nanomaterials for hyperthermia-based therapy focused primarily on magnetic fluid hyperthermia (MFH) using mono metallic/metal oxide nanoparticles. The term “Hyperthermia” in the literature was also confined only to include use of heat for therapeutic applications. Recently, there have been a number of publications demonstrating magnetic nanoparticle-based hyperthermia to generate local heat resulting in the release of drugs either bound to the magnetic nanoparticle or encapsulated within polymeric matrices. In this review article, we present a case for broadening the meaning of the term “hyperthermia” by including thermotherapy as well as magnetically modulated controlled drug delivery. We provide a classification for controlled drug delivery using hyperthermia: Hyperthermia-based controlled Drug delivery through Bond Breaking (DBB) and Hyperthermia-based controlled Drug delivery through Enhanced Permeability (DEP). The review also covers, for the first time, core-shell type magnetic nanomaterials, especially nanoshells prepared using layer-by-layer self-assembly, for the application of hyperthermia-based therapy and controlled drug delivery. The highlight of the review article is to portray potential opportunities in the combination of hyperthermia-based therapy and controlled drug release paradigms for successful application in personalized medicine.

Subfields: Biomaterials, Biomedical Engineering, Electronic, Optical and Magnetic Materials

View Paper: https://www.semanticscholar.org/paper/094287b6e3a298702d7b5d2241bbc2bbf0400786

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In Biomedical Engineering

1. Fabian Kiessling
2. T. Lammers

Citations in the corpus

• Iron Oxide Nanoparticles: Diagnostic, Therapeutic and Theranostic Applications (2019, background): “The main effect is based on the increase of the temperature above 42 °C and to the resulting denaturation of proteins, together leading to cell death [216] (Fig.”