Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution

By J. Smith, Shigehiro Kuraku, Carson Holt, T. Sauka-Spengler, Ning Jiang, Michael Campbell, Mark Yandell, T. Manousaki, Axel Meyer, O. Bloom and 49 more. Nature Genetics, 2013

639 citations recorded by the source corpus.

Lampreys are representatives of an ancient vertebrate lineage that diverged from our own ∼500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) genome is uniquely poised to provide insight into the ancestry of vertebrate genomes and the underlying principles of vertebrate biology. Here, we present the first lamprey whole-genome sequence and assembly. We note challenges faced owing to its high content of repetitive elements and GC bases, as well as the absence of broad-scale sequence information from closely related species. Analyses of the assembly indicate that two whole-genome duplications likely occurred before the divergence of ancestral lamprey and gnathostome lineages. Moreover, the results help define key evolutionary events within vertebrate lineages, including the origin of myelin-associated proteins and the development of appendages. The lamprey genome provides an important resource for reconstructing vertebrate origins and the evolutionary events that have shaped the genomes of extant organisms.

Subfields: Genetics, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/09409e4dc44fbe4ae317ba226433be6f42f6f508

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Mark Yandell
2. Carson Holt
3. Stephen Fitzgerald
4. Javier Herrero
5. Kathryn M Beal
6. Albert J. Vilella
7. Ning Jiang
8. Paul Flicek

In Molecular Biology

1. Mark Yandell
2. Carson Holt
3. Stephen Fitzgerald
4. Leo Gordon
5. S. Searle
6. Javier Herrero
7. Kathryn M Beal
8. Simon Brent

In Plant Science

1. Stephen Fitzgerald
2. Javier Herrero
3. Kathryn M Beal
4. Albert J. Vilella
5. Mark Yandell
6. Ning Jiang
7. Shin-Han Shiu
8. Paul Flicek

Citations in the corpus

• MAKER-P: A Tool Kit for the Rapid Creation, Management, and Quality Control of Plant Genome Annotations1[W][OPEN] (2013, background): “Not only is MAKER portable and easy to use, it is already in wide use by the animal, and fungal research communities (Kumar et al., 2012; Amemiya et al., 2013; Eckalbar et al., 2013; Schardl et al., 2013; Smith et al., 2013).”
• Ensembl comparative genomics resources (2016, background): “Indeed, the Ensembl comparative genomics resources have contributed directly to the analysis and interpretation of several genome sequencing projects including the orang-utan (60), gorilla (61), tammar wallaby (62), chicken (63), turkey (64), zebra finch (65) and lamprey (66).”
• Ensembl comparative genomics resources (2016, background): “Indeed, the Ensembl comparative genomics resources have contributed directly to the analysis and interpretation of several genome sequencing projects including the orang-utan (60), gorilla (61), tammar wallaby (62), chicken (63), turkey (64), zebra finch (65) and lamprey (66).”