Glucocorticoid regulation of inflammation and its behavioral and metabolic correlates: from HPA axis to glucocorticoid receptor dysfunction
By M. N. Silverman, Esther M. Sternberg. Annals of the New York Academy of Sciences, 2012
678 citations recorded by the source corpus.
Enhanced susceptibility to inflammatory and autoimmune disease can be related to impairments in HPA axis activity and associated hypocortisolism, or to glucocorticoid resistance resulting from impairments in local factors affecting glucocorticoid availability and function, including the glucocorticoid receptor (GR). The enhanced inflammation and hypercortisolism that typically characterize stress‐related illnesses, such as depression, metabolic syndrome, cardiovascular disease, or osteoporosis, may also be related to increased glucocorticoid resistance. This review focuses on impaired GR function as a molecular mechanism of glucocorticoid resistance. Both genetic and environmental factors can contribute to impaired GR function. The evidence that glucocorticoid resistance can be environmentally induced has important implications for management of stress‐related inflammatory illnesses and underscores the importance of prevention and management of chronic stress. The simultaneous assessment of neural, endocrine, and immune biomarkers through various noninvasive methods will also be discussed.
Subfields: Behavioral Neuroscience, Endocrinology, Diabetes and Metabolism
View Paper: https://www.semanticscholar.org/paper/09343065bb32bce26c388cfe67cf2c55f4c52134
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In Behavioral Neuroscience
In Endocrinology, Diabetes and Metabolism
Citations in the corpus
- Diurnal Cortisol Slopes and Mental and Physical Health Outcomes:A Systematic Review and Meta-analysis (2017, positive): “…which specific types of health outcomes would be most strongly associated with flatter cortisol slopes, although we expected immune and inflammatory outcomes to show robust associations, given the key role played by glucocorticoids in regulating inflammation (Silverman and Sternberg, 2012).”
- Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile (2013, background): “A wide range of studies showed that pro-inflammatory cytokines may promote the release of CRH, ACTH and cortisol by acting directly on hypothalamic and pituitary cells and disrupting GR function leading to glucocorticoid resistance [112,113].”
- Glucocorticoid receptor signaling in health and disease (2013, background): “Elevation in glucocorticoids has been implicated in psychiatric disorders such as schizophrenia, drug addiction, posttraumatic stress disorder (PTSD) and mood disorders [43].”