Bone-Graft Substitutes: Facts, Fictions, and Applications

By A. Greenwald, S. D. Boden, V. M. Goldberg, Yusuf M. Khan, C. Laurencin, R. Rosier. Journal of Bone and Joint Surgery. American volume, 2001

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Strategies for Controlled Delivery of Growth Factors and Cells for Bone Regeneration (2012, background): “Every year, more than 500,000 bone graft procedures are performed to address bone fractures and other orthopedic-related injuries resulting from a variety of surgical, degenerative and traumatic causes [1, 2].”
Bone substitutes in orthopaedic surgery: from basic science to clinical practice (2014, background): “year, with more than 500,000 implanted in the US alone [2–5].”
Sol-gel based materials for biomedical applications (2016, background): “Degradation of the polymers is based on enzymatic or hydrolytic pathways [474,475].”
Bone regenerative medicine: classic options, novel strategies, and future directions (2014, background): “Degradation of the polymers is based on enzymatic or hydrolytic pathways [34,70].”