5 year mortality predictors in 498,103 UK Biobank participants: a prospective population-based study.

By A. Ganna, E. Ingelsson. 2015

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Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population (2017, neutral): “Although the UK Biobank Study is still in the early stages as a prospective study, initial publications have shown expected associations of cardiometabolicmorbidity, self-reported health, and smokingwithmortality risk (30, 31).”
Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults Implications for Primary Prevention (2019, background): “Second, the UK Biobank has a minimum enrollment age of 40 years, and participants have been shown to be healthier than the UK general population (22,23); thus, our study may have underestimated population-level lifetime CAD risk.”
Collider scope: when selection bias can substantially influence observed associations (2016, background): “Unsurprisingly, therefore, participants in UK Biobank have far lower rates of 5-year mortality than the UK population as a whole.(40) Clearly, agreeing to take part”
Model-Based Generation of Large Databases of Cardiac Images: Synthesis of Pathological Cine MR Sequences From Real Healthy Cases (2018, background): “Nonetheless, it targets an outpatient or normal population, which means that the study of specific pathologies in coherent subgroups might still have limited sample size or be subject to a large variety of confounding factors [7].”