Nanostructures in biodiagnostics.
By Nathaniel L. Rosi, Chad A. Mirkin. Chemical Reviews, 2005
4,152 citations recorded by the source corpus.
In the last 10 years the field of molecular diagnostics has witnessed an explosion of interest in the use of nanomaterials in assays for gases, metal ions, and DNA and protein markers for many diseases. Intense research has been fueled by the need for practical, robust, and highly sensitive and selective detection agents that can address the deficiencies of conventional technologies. Chemists are playing an important role in designing and fabricating new materials for application in diagnostic assays. In certain cases assays based upon nanomaterials have offered significant advantages over conventional diagnostic systems with regard to assay sensitivity, selectivity, and practicality. Some of these new methods have recently been reviewed elsewhere with a focus on the materials themselves or as subclassifications in more generalized overviews of biological applications of nanomaterials.1-7 We intend to review some of the major advances and milestones in the field of detection systems based upon nanomaterials and their roles in biodiagnostic screening for nucleic acids, * To whom correspondence should be addressed. Phone: 847-4913907. Fax: 847-467-5123. E-mail: chadnano@northwestern.edu. Nathaniel L. Rosi earned his B.A. degree at Grinnell College (1999) and his Ph.D. degree from the University of Michigan (2003), where he studied the design, synthesis, and gas storage applications of metal−organic frameworks under the guidance of Professor Omar M. Yaghi. In 2003 he began postdoctoral studies as a member of Professor Mirkin’s group at Northwestern University. His current research focuses on the rational assembly of DNA-modified nanostructures into larger-scale materials.
Subfields: Biomedical Engineering, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/08a717ebb0f48c3831d894b20965559af62c09ed
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biomedical Engineering
In Molecular Biology
- Xiaohua Huang
- M. El-Sayed
- Juewen Liu
- I. El-Sayed
- Vincent Rotello
- Indrajit Roy
- D. Giljohann
- Ken-Tye Yong
Citations in the corpus
- Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles (2010, background): “General reviews about the application of nanoparticles in biological systems can be found in a number of articles (Riu et al. 2006; De et al. 2008) focusing on analytics (Rosi & Mirkin 2005; Wilson 2008), gold nanoparticles Phil.”
- DNA stabilized fluorescent metal nanoclusters for biosensor development (2014, background): “Attaching DNA allows stimuli-responsive modulation of interparticle distance or the distance between a particle and an organic fluorophore, generating a change in optical signals [6-10].”
- Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice. (2008, background): “[14], and catalytic [15] properties have been exploited in the areas of cancer imaging [2,16–19], diagnostics [6,20,21], and treatment [22–30].”
- Drivers of biodiagnostic development (2009, background): “Many of these advances rely on nanoscale materials, which have attractive properties for such assays: they have unique and controllable size-dependent properties, have tunable chemical compositions, and in certain cases are chemically and physically robust structure”