Detection of Macular Ganglion Cell Loss in Glaucoma by Fourier-Domain Optical Coherence Tomography
By O. Tan, V. Chopra, A. Lu, J. Schuman, H. Ishikawa, R. Varma, David Huang. Ophthalmology (Rochester, Minn.), 2009
614 citations recorded by the source corpus.
Purpose To map ganglion cell complex thickness with high-speed Fourier-domain optical coherence tomography (FD-OCT) and compute novel macular parameters for glaucoma diagnosis. Design Observational, cross-sectional study. Participants One hundred seventy-eight participants in the Advanced Imaging for Glaucoma Study, divided into three groups: 65 persons in the normal group (N), 78 in the perimetric glaucoma group (PG), and 52 in the pre-perimetric glaucoma group (PPG). Methods The RTVue FD-OCT system was used to map the macula over a 7×6 mm region. The macular OCT images were exported for automatic segmentation using software we developed. The program measured macular retinal (MR) thickness and ganglion cell complex (GCC) thickness. The GCC was defined as the combination of nerve fiber, ganglion cell, and inner plexiform layers. Pattern analysis was applied to the GCC map and the diagnostic power of pattern-based diagnostic parameters were investigated. Results were compared to time-domain (TD) Stratus OCT measurements of MR and circumpapillary nerve fiber layer (NFL) thickness. Main Outcome Measures Repeatability was assessed by intraclass correlation (ICC), pooled standard deviation, and coefficient of variation. Diagnostic power was assessed by the area under the receiver operator characteristic (AROC) curve. Measurements in the PG group were the primary measures of performance. Results The FD-OCT measurements of MR and GCC averages had significantly better repeatability than TD-OCT measurements of MR and NFL averages. The FD-OCT GCC average had significantly (P=0.02) higher diagnostic power (AROC = 0.90) than MR (AROC = 0.85 for both FD-OCT & TD-OCT) in differentiating between PG and N. One GCC pattern parameter, global loss volume, had significantly higher AROC (0.92) than the overall average (P=0.01). The diagnostic powers of the best GCC parameters were statistically equal to TD-OCT NFL average. Conclusions The higher speed and resolution of FD-OCT improved the repeatability of macular imaging compared to standard TD-OCT. Ganglion cell mapping and pattern analysis improved diagnostic power. The improved diagnostic power of macular GCC imaging is on par with, and complementary to, peripapillary NFL imaging. Macular imaging with FD-OCT is a useful method for glaucoma diagnosis and has potential for tracking glaucoma progression.
Subfields: Biomedical Engineering, Ophthalmology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/0884a9b42c19aa6e85048bad0cef8309942effd1
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biomedical Engineering
In Ophthalmology
In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration (2014, methodology): “org) in 3 layers using an automated algorithm.(34,35) The inner retinal layer was defined from the internal limiting membrane to the outer boundary of the outer plexiform layer (OPL).”