Molecular logic of neocortical projection neuron specification, development and diversity

By Luciano C. Greig, Mollie B. Woodworth, Maria J. Galazo, H. Padmanabhan, J. D. Macklis. Nature Reviews Neuroscience, 2013

819 citations recorded by the source corpus.

The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of neuronal subtypes generated during development under precise molecular regulation. In recent years, several key controls over the specification and differentiation of neocortical projection neurons have been identified. This work provides substantial insight into the 'molecular logic' underlying cortical development and increasingly supports a model in which individual progenitor-stage and postmitotic regulators are embedded within highly interconnected networks that gate sequential developmental decisions. Here, we provide an integrative account of the molecular controls that direct the progressive development and delineation of subtype and area identity of neocortical projection neurons.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/0863754637ff57d920f6ac8df8fca9a1a50f43cd

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Citations in the corpus

• Molecularly Defined Circuitry Reveals Input-Output Segregation in Deep Layers of the Medial Entorhinal Cortex (2015, background): “While differences in the molecular make-up of neuronal populations often correlate with specific axonal projection targets (Greig et al., 2013; Kitamura et al., 2014; Varga et al., 2010), it is not known if the molecular identity or location of neurons in deep layers of MEC map onto their connectivi”
• Adult Mouse Cortical Cell Taxonomy by Single Cell Transcriptomics (2016, neutral): “In the adult cortex, many types of neurons have been identified through characterization of their molecular, morphological, connectional, physiological and functional properties 4–8 .”