Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia

By Lan Wang, Guang-Biao Zhou, Ping Liu, Jun Song, Yang Liang, Xiao-jing Yan, Fang Xu, Bing-Shun Wang, J. Mao, Zhi-xiang Shen and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2008

747 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/085a8c866336466c394b39795492387893b6ff6b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Shao Li
2. Ningbo Zhang
3. Bo Zhang
4. Shao Li

Citations in the corpus

• Systems medicine: the future of medical genomics and healthcare (2009, neutral): “starting to bear fruit [192,212,213].”
• How Can Synergism of Traditional Medicines Benefit from Network Pharmacology? (2017, background): “It was evident that tetraarsenic tetrasulfide was the principal component among the three active ingredients, whereas tanshinone IIA and indirubin had an ancillary function [40].”
• Natural products and drug discovery (2009, background): “Its synergistic effect was recently attributed to the direct anti-cancer properties of tetra-arsenic tetrasulphide from Realgar and the complementary effects of indirubin and tanshinone IIA from Indigo naturalis and Radix salviae miltiorrhizae , respectively, which enhance the transport of tetra-”
• Network target for screening synergistic drug combinations with application to traditional Chinese medicine (2011, background): “For instance, the Realgar-Indigo naturalis Formula has an effect on promyelocytic leukemia via the action mechanism of synergy among its components [23].”
• Traditional Chinese medicine network pharmacology: theory, methodology and application. (2013, background): “to identify the active ingredients in TCMs and their biological targets ([5-11]).”