The unfolded protein response

By Chuan-Yin Liu, R. Kaufman. Journal of Cell Science, 2003

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Stress granule assembly is mediated by prion-like aggregation of TIA-1. (2004, background): “We also analyzed components of the endoplasmic-reticulum stress-induced pathway (Harding et al., 2002; Liu and Kaufman, 2003) and find that ATF4 and GADD34 mRNAs are not induced by HA-PRD, nor is processing of XBP-1 mRNA detected.”
Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease (2014, background): “Basic and clinical studies in the last decade suggest that ROS crucially impacts the pathogenesis of many human diseases, including metabolic disease, neurodegenerative disease, inflammatory disease, neoplasms, as well as pathologies in the heart, kidney, and lung (6, 20, 178).”
Integrating Mechanisms for Insulin Resistance: Common Threads and Missing Links (2012, neutral): “Liver-speciﬁc JNK1 deletion actually promotes hepatic steatosis, associated with increased expression of key lipogenic enzymes, impaired insulin signaling, and hepatic insulin resistance (Zhang et al., 2011b).”