Fragment library design: efficiently hunting drugs in chemical space.

34 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

A Role for Fragment-Based Drug Design in Developing Novel Lead Compounds for Central Nervous System Targets (2015, methodology): “Fragments are drawn from three sources: known biologically active drugs, natural products, and compounds with novel scaffolds (20).”
Visualisation and subsets of the chemical universe database GDB-13 for virtual screening (2011, background): “The discovery of innovative chemotypes is one of the key chemical problems in small molecule drug discovery, in particular at the level of fragments, a size range which also includes many drugs [1–8].”