Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation

By I. Galve-Roperh, C. Sánchez, M. Cortés, T. G. D. Pulgar, M. Izquierdo, M. Guzmán. Nature Medicine, 2000

670 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The Endocannabinoid System as an Emerging Target of Pharmacotherapy (2006, methodology): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript 2005), c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase (Galve-Roperh et al., 2000; Sarker et al., 2003; Hinz et al., 2004; Powles et al., 2005).”
Potentiation of cannabinoid-induced cytotoxicity in Mantle Cell Lymphoma through modulation of ceramide metabolism (2009, positive): “The production of ceramide following treatment with cannabinoids can be caused by either hydrolysis of sphingomyelin or de novo ceramide synthesis (34, 35).”
Cannabis and the brain. (2003, background): “In a remarkable study injections of THC into solid tumours of C6 glioma in rodent brain led to increased survival times, and a complete eradication of the tumours was evident in 20±35% of the treated animals (Galve-Roperh et al., 2000).”
Pharmacokinetics and Pharmacodynamics of Cannabinoids (2003, background): “[213] Cannabinoid agonists inhibited human breast cancer cell proliferation in vitro,[214,215] and, directly applied at the tumour site, showed antineoplastic activity against malignant gliomas in rats.[216]”