p53 in the DNA damage repair process
By Ashley B. Williams, B. Schumacher. Cold Spring Harbor Perspectives in Medicine, 2016
704 citations recorded by the source corpus.
The cells in the human body are continuously challenged by a variety of genotoxic attacks. Erroneous repair of the DNA can lead to mutations and chromosomal aberrations that can alter the functions of tumor suppressor genes or oncogenes, thus causing cancer development. As a central tumor suppressor, p53 guards the genome by orchestrating a variety of DNA damage response (DDR) mechanisms. Already early in metazoan evolution, p53 started controlling the apoptotic demise of genomically compromised cells. p53 plays a prominent role as a facilitator of DNA repair by halting the cell cycle to allow time for the repair machineries to restore genome stability. In addition, p53 took on diverse roles to also directly impact the activity of various DNA repair systems. It thus appears as if p53 is multitasking in protecting from cancer development by maintaining genome stability.
Subfields: Biotechnology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/078cc6da639a1114670839e26caba084f1cb6db8
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Citations in the corpus
- Breast Cancer—Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies—An Updated Review (2021, background): “P53 protein is essential for normal cellular homeostasis and genome maintenance by mediating cellular stress responses including cell cycle arrest, apoptosis, DNA repair, and cellular senescence [225].”
- Targeting p53 pathways: mechanisms, structures and advances in therapy (2023, background): “When DNA is damaged, p53 protects the genome by coordinating multiple DNA damage response mechanisms.(51) The p53 protein activates the expression of DNA repair proteins DDB2 and XPC.”