Carbon Nanoparticle-based Fluorescent Bioimaging Probes
By S. Bhunia, A. Saha, A. Maity, S. Ray, N. Jana. Scientific Reports, 2013
674 citations recorded by the source corpus.
Fluorescent nanoparticle-based imaging probes have advanced current labelling technology and are expected to generate new medical diagnostic tools based on their superior brightness and photostability compared with conventional molecular probes. Although significant progress has been made in fluorescent semiconductor nanocrystal-based biological labelling and imaging, the presence of heavy metals and the toxicity issues associated with heavy metals have severely limited the application potential of these nanocrystals. Here, we report a fluorescent carbon nanoparticle-based, alternative, nontoxic imaging probe that is suitable for biological staining and diagnostics. We have developed a chemical method to synthesise highly fluorescent carbon nanoparticles 1–10 nm in size; these particles exhibit size-dependent, tunable visible emission. These carbon nanoparticles have been transformed into various functionalised nanoprobes with hydrodynamic diameters of 5–15 nm and have been used as cell imaging probes.
Subfields: Biomedical Engineering, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/078add323ed41ecc9f624a5dc57e0f8881726326
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In Biomedical Engineering
In Materials Chemistry
Citations in the corpus
- Crossing the blood‐brain barrier with nanoparticles (2018, background): “Instead, most carbon dots (CDs) have an ultra-small size (1–10 nm) and versatile surface functionalities [64], which would be in favor of the delivery of large drug molecules via the carrier-mediated transport by covalently conjugating with drugs [55].”
- The photoluminescence mechanism in carbon dots (graphene quantum dots, carbon nanodots, and polymer dots): current state and future perspective (2015, background): “The most common CDs have strong PL from blue to green, and a few CDs possess optimal emission in long-wavelength regions [23, 28, 63].”