The ELF4-ELF3-LUX Complex Links the Circadian Clock to Diurnal Control of Hypocotyl Growth
By Dmitri A. Nusinow, A. Helfer, Elizabeth E. Hamilton, Jasmine J. King, T. Imaizumi, T. F. Schultz, E. Farré, Steve A. Kay. Nature, 2011
840 citations recorded by the source corpus.
The circadian clock is required for adaptive responses to daily and seasonal changes in environmental conditions. Light and the circadian clock interact to consolidate the phase of hypocotyl cell elongation to peak at dawn under diurnal cycles in Arabidopsis thaliana. Here we identify a protein complex (called the evening complex)—composed of the proteins encoded by EARLY FLOWERING 3 (ELF3), ELF4 and the transcription-factor-encoding gene LUX ARRHYTHMO (LUX; also known as PHYTOCLOCK 1)—that directly regulates plant growth. ELF3 is both necessary and sufficient to form a complex between ELF4 and LUX, and the complex is diurnally regulated, peaking at dusk. ELF3, ELF4 and LUX are required for the proper expression of the growth-promoting transcription factors encoded by PHYTOCHROME INTERACTING FACTOR 4 (PIF4) and PIF5 (also known as PHYTOCHROME INTERACTING FACTOR 3-LIKE 6) under diurnal conditions. LUX targets the complex to the promoters of PIF4 and PIF5 in vivo. Mutations in PIF4 and/or PIF5 are epistatic to the loss of the ELF4–ELF3–LUX complex, suggesting that regulation of PIF4 and PIF5 is a crucial function of the complex. Therefore, the evening complex underlies the molecular basis for circadian gating of hypocotyl growth in the early evening.
Subfields: Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/073ea6f4108a2608e208f99c6e5490e68de9b596
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Citations in the corpus
- Light quality in plant tissue culture: does it matter? (2018, background): “Similarly, high expression of TOC1, gigantea (GI), early flowering 3 and 4, and luxarrhythmo (LUX) genes are identified at night (Lu et al. 2009; Nusinow et al. 2011).”
- Shade Avoidance (2012, positive): “PIL1 expression shows a strong and rapid promotion by low R:FR (Salter et al., 2003), which depends on PIF4 and PIF5 (Lorrain et al., 2008).”