Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist.

By Sama I Sayin, A. Wahlström, Jenny E Felin, S. Jäntti, Hanns-Ulrich Marschall, K. Bamberg, B. Angelin, T. Hyötyläinen, Matej Oresic, F. Bäckhed. Cell Metabolism, 2013

2,147 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/06f535d8fef9d2056cf10e85cea0def801aaf95f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. F. Bäckhed
2. Robert Caesar
3. V. Tremaroli
4. M. Schoeler
5. F. Marra
6. G. Svegliati-Baroni
7. Stanley L Hazen
8. P. Kovatcheva-Datchary

In Oncology

1. Hanns-Ulrich Marschall
2. F. Bäckhed

In Surgery

1. G. Svegliati-Baroni
2. F. Marra
3. F. Bäckhed
4. Hanns-Ulrich Marschall

Citations in the corpus

• Lipotoxicity and the gut-liver axis in NASH pathogenesis. (2018, background): “As an example, accumulation of the murine taurine-conjugated primary bile acids Tauro-α and β- muricholic acid (T-α-MCA and T-β-MCA) has been found to antagonize FXR signaling in the ileum in germ-free mice, whereas the presence of intestinal microbiota led to FXR activation, thus influencing BAs sy”