Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue

By Zheng-long Yuan, Ying-Jie Guan, D. Chatterjee, Y. E. Chin. Science, 2005

821 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/06e80618c8e64d481d353adae76dc99fdcdd528c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. S. Grivennikov
2. M. Karin
3. Huiyuan Zhang
4. Gautam Sethi
5. E. Seto
6. Ivana Samaržija
7. Xiang-Jiao Yang
8. N. Perkins

In Molecular Biology

1. Xiang-Jiao Yang
2. S. Grivennikov
3. E. Seto
4. M. Karin
5. Gautam Sethi
6. Ivana Samaržija
7. N. Perkins
8. Zena Werb

In Oncology

1. M. Karin
2. S. Grivennikov
3. E. Seto
4. Ivana Samaržija
5. Xiang-Jiao Yang
6. N. Perkins
7. T. Hirano
8. Bharat B. Aggarwal

Citations in the corpus

• Histone Deacetylase Inhibitors: Overview and Perspectives (2007, neutral): “HDAC1, HDAC2, and HDAC3 were shown to coimmunoprecipitate with the ATP-dependent chaperone protein heat shock protein 70 (20).”
• STAT3 signaling in immunity (2016, background): “methylation have been implicated more recently in STAT3 transcriptional function [32–35].”
• Lysine acetylation: codified crosstalk with other posttranslational modifications (2008, background): “In addition, STAT3 acetylation is known to Molecular Cell 31, August 22, 2008 ª2008 Elsevier Inc. 455 promote its homodimerization and nuclear localization (Yuan et al., 2005).”
• Post-Translational Modifications That Drive Prostate Cancer Progression (2021, background): “Enzyme Involvement(s) in Prostate Cancer Ref. p300 regulates fatty acid synthase expression, lipid metabolism and PCa growth [313] p300 regulates AR degradation and PTEN-deficient prostate tumorigenesis [314] The assembly of a macromolecular complex involving CBP/p300 results in acetylation of p53 a”
• Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. (2007, background): “Other reports show that STAT3 has an effect on CRE-like sites in the C/EBPB promoter (Niehof et al. 2001) and the glucocorticoid response element (Zhang and Fuller 1997; Zhang et al. 1999), which lack classical GAS sequences.”
• Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. (2014, background): “STAT3 is also acetylated on a single lysine residue 685 by histone acetyltransferase p300 [105], which was found to be critical for the formation of stable dimers.”
• Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer (2009, background): “fine tunes of STAT3 activity, is its reversible acetylation (38), which also affects the activity of NF-κB family members (39).”