Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway

By V. Boussiotis. New England Journal of Medicine, 2016

1,138 citations recorded by the source corpus.

The PD-1 pathway plays an essential role in maintaining immunologic self-tolerance. However, cancers can subvert the role of this pathway and blind the immune system to their presence. The molecular details of the pathway are discussed.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/06571ee1d107b8f00ec44ec4639b9df38b472966

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Citations in the corpus

PD-1/PD-L1 pathway: current researches in cancer. (2020, background): “In addition, miR-155 enhances PD-L1 expression of lymphoma cells, recruits CD8- T cells through PD-1/PD-L1 interaction, and inhibits CD8- T-cell function by dephosphorylating AKT and ERK [57].”
Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies (2020, background): “Treatments with antibodies targeting PD-1/PD-1 ligands have elicited an increased response in different cancer types and, in tandem with antibodies targeting cytotoxic-Tlymphocyte-associated antigen-4, have changed cancer therapy radically (71).”
Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4 (2019, background): “In contrast to CTLA-4, PD-1 plays a major role in the maintenance of peripheral tolerance [33].”
Cholesterol induces CD8+ T-cell exhaustion in the tumor microenvironment (2019, neutral): “T-cell receptor activation (Boussiotis, 2016), a myriad of transcription factors, such as STAT3, STAT4, NFATc1, T-bet, and Blimp-1 (Austin et al., 2014; Kao et al., 2011; Lu et al., 2014a) and epigenetic components, including DNA methylation and histone modification (Bally et al., 2016; Stephen et…”