The organizing principle: microenvironmental influences in the normal and malignant breast.

By Mina J. Bissell, Derek C. Radisky, A. Rizki, Valerie M. Weaver, O. Petersen. Differentiation; research in biological diversity, 2002

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The Use of 3-D Cultures for High-Throughput Screening: The Multicellular Spheroid Model (2004, background): “Threedimensional heterotypic collagen assays that were primarily applied in the past few years to resemble breast epithelial morphogenesis and neoplasia are a promising approach that could also be useful for antitumor drug screening.(47,49) In the anticancer drug development arena, multiple in vitro”
Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. (2006, background): “, 2004) or suppress (Bissell et al., 2002; Matrisian et al., 2001) cancer progression through signaling mechanisms.”
The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells (2009, background): “A growing literature indicates that the biomechanical properties of cells and the surrounding ECM directly influence and are influenced by the progression of neoplastic disease (17, 18).”
Mutant p53 Disrupts Mammary Acinar Morphogenesis via the Mevalonate Pathway (2012, positive): “Each acinus consists of a single layer of polarized luminal epithelial cells surrounding a hollow lumen (Bissell et al., 2002).”