Aneurysm Syndromes Caused by Mutations in the TGF-β Receptor

By B. Loeys, U. Schwarze, Tammy M. Holm, B. Callewaert, G. Thomas, H. Pannu, J. De Backer, Gretchen L. Oswald, S. Symoens, S. Manouvrier and 11 more. 2006

1,338 citations recorded by the source corpus.

Subfields: Genetics, Pulmonary and Respiratory Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/05aa6c0a378361cfe5a8366781a95f7659b3e0d4

How researchers see this paper

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In Genetics

1. J. Massagué

In Pulmonary and Respiratory Medicine

1. J. Massagué
2. E. Hay

Citations in the corpus

• Mutations in smooth muscle α-actin (ACTA2) lead to thoracic aortic aneurysms and dissections (2007, background): “TAAD results from diverse etiologies, including infectious agents, hemodynamic forces and genetic syndromes, but studies have established that at least 20% of affected individuals have a genetic predisposition for TAAD inherited primarily in an autosomal dominant manner with decreased penetrance and”
• TGFβ in Cancer (2008, result): “Inhibition of TGFβ receptor function might also lead to runaway compensatory mechanisms by other activators of the Smad pathway, similar to what occurs in individuals with inactivating mutations in TGFBRI or TGFBRII (Loeys et al., 2006).”